Fidaxomicin Good Supplier In Bulk Supply High Purity 873857-62-6 We supply high quality Fidaxomicin (CAS 873857-62-6), in stock, factory directly supply to clients, lower prices, more competitiveness.
What is the Fidaxomicin ?
Fidaxomicin is , while it's Molecular Formula is C52H74Cl2O18. Fidaxomycin is a natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria (IC50s = 0.4 and 6 μM, respectively). It has potent antibacterial activity against most Gram-positive bacteria and effectively targets the Gram-positive C. difficile (MIC = 12 ng/ml). Orally administered fidaxomycin exhibits minimal systemic bioavailability resulting in maximal gastrointestinal tract distribution. Fidaxomycin is effective in clearing C. difficile infections while sparing Gram-negative bacteria in the gut.[Cayman Chemical]
What is the CAS number for Fidaxomicin ?
The CAS number of Fidaxomicin is 873857-62-6.
More information of Fidaxomicin 873857-62-6 are:
|
Synonyms |
R-Tiacumicin B;Tiacumicin B;OPT-80;PAR-101;3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-b-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-b-D-lyxo-hexopyranosyl)oxy]-11(S)-ethyl-8(S)-hydroxy-18(S)-(1(R)-hydroxyethyl)-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaene-2-one;Lipiarmycin; |
|
CAS?Number |
873857-62-6 |
|
Molecular Formula |
C52H74Cl2O18 |
|
Molecular Weight |
1058.04 |
|
Density |
1.33 |
|
Melting Point |
161 °C |
|
Boiling Point |
1046.4±65.0 °C(Predicted) |
|
HS CODE |
2941900000 |
|
PSA |
266.66000 |
|
LogP |
6.23440 |
|
Pka |
5.09±0.35(Predicted) |
What is Fidaxomicin (873857-62-6) used for?
Fidaxomicin (OPT-80) was approved by the U.S. FDA in May 2011 for the treatment of Clostridium difficile-associated diarrhea (CDAD), joining metronidazole and vancomycin as drugs recommended for treatment of C. difficile infections (CDI). Fidaxomicin, also known as lipiarmycin and tiacumicin, is an 18-membered macrolide natural product that was first reported in mid-1970s and is produced by fermentation. Fidaxomicin and its primary metabolite OP-1118, which results from hydrolysis of the isobutyryl ester, are narrowspectrum antibacterial agents with activity against gram-positive aerobic and anaerobic organisms, but not against gram-negative organisms. Fidaxomicin and OP-1118 exert their antibacterial activity by inhibiting bacterial RNA polymerase, thereby inhibiting bacterial protein synthesis. The MIC90 (minimum inhibitory concentration to kill 90% of bacteria) for fidaxomicin against C.difficile is 0.125–0.25 μg/mL; OP- 1118 is 4- to 16-fold less potent than the parent compound. Fidaxomicin has been reported to spare native intestinal flora such as Bacteroides spp. and as such, may prevent selection of drug-resistant bacteria. Fidaxomicin is bactericidal to C. difficile and has a low propensity for resistance development with no cross-resistance to existing antibiotics. Fidaxomicin shows minimal systemic absorption following oral administration in preclinical studies and humans.
Articles related to Fidaxomicin:
How to get the best price on Fidaxomicin?
Shijiazhuang Hengsikai Chemical Import and Export Co.,Ltd is a quality supplier and manufacturer of Fidaxomicin . You can buy high quality, low price Fidaxomicin 873857-62-6 here. Contact us.
